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In addition, the pectin content, cation exchange capacity (CEC) and pectin methylesterase (PME) activity were also increased in the SiO 2 NPs-pretreated cells, leading to a decreased degree of pectin methylesterification and an improved mechanical force of the cell walls

This included a transformed human cell line for osteosarcoma, U2OS, a mouse melanoma cell line, B16-F10, and primary human immune cellsmonocytes (Fig